Independent Confirmation of Association between Metabolic Phenotypes of Polycystic Ovary Syndrome and Variation in the Type 6 17β-Hydroxysteroid Dehydrogenase Gene

摘要

Context: Few candidate genes for polycystic ovary syndrome (PCOS) are widely agreed upon largely due to lack of replication. Type 6 17β-hydroxysteroid dehydrogenase (HSD17B6) gene expression is increased in PCOS ovarian theca. Previous genetic study of HSD17B6 reported significant association of rs898611 with PCOS risk and metabolic phenotypes.